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报告题目：Dynamics of HIFU (High Intensity Focused Ultrasound) for Biomedical and Dentistry Application

报告人：B. C. Khoo（National University of Singapore）

时间：2017年1月3日上午10:40

地点：船海楼15楼大会议室

主办单位：科学技术研究院

承办单位：船舶工程学院

报告人简介：

Academic/Professional Qualifications:

ØBA Hons. 1st Class with Distinction (1980), University of Cambridge

ØMEng (1984), National University of Singapore

ØPhD (1989), Massachusetts Institute of Technology

Administrative Leadership:

ØProgram Chair and SMA (Singapore-MIT Alliance) Fellow in SMA-I (1999-2004) and SMA-II (2005-present)

ØInternational Steering Committee, HPC (High Performance Computing) Asia (1999-present)

ØDeputy Director, Institute of High Performance Computing (1998-1999)

ØDeputy Director, Centre for Computational Mechanics (1995-1998)

ØTask Force for the Singapore BioMed Grid (BMG)

Awards & Prizes:

ØAwarded the Royal Aeronautical Prize (London), 1980.

ØThe prestigious Defense Technology Prize for team effort in 1998 was awarded to the Underwater Shock Technology Program, Singapore.

ØLiterati Club Awards for Excellence 1999 for Numerical Simulation of turbulent flow in an axisymmetric diffuser with a curved surface center-body published in International Journal of Numerical Methods for Heat and Fluid Flow.

报告简介:

We study the physical phenomena and the application of HIFU (High Intensity Focused Ultrasound) using simulation and experiment. Experiments were done with a bowl-shaped focused ultrasound system. High speed videos of the generation of cavitation bubbles at the focal point of the HIFU are captured. We observed interesting bubble cloud structures, bubble movements and stationary bubble oscillations. The system is then applied for dentistry applications. Firstly we use the HIFU to drive antibacterial nanoparticles into dentinal tubules for disinfection in root canal treatment. Initial results show delivery of these nanoparticle deep into the dentinal channels which are a few microns in size. Next we cultivate E. Faecalis biofilm, a common bacteria colony found in the mouth and teeth, on petri dish and in human tooth. Then we subject them for removal under strong HIFU for a period of time. We obtain positive results in the biofilm removal with the increasing HIFU sonification time. Separately, we simulate the interaction of a bubble with pulsed ultrasound and in an ultrasound field near bio-materials such as fat, muscle and bone. The simulation shows extreme growth and collapse of the bubble under certain conditions. It is found that the formation and direction of the water jet during bubble collapse is highly dependent on the properties of the bio-materials nearby. These studies provide a foundation for better understanding of HIFU and its uses in medical treatment.